Targeted Disruption of the Methionine Synthase Gene in Mice
نویسندگان
چکیده
منابع مشابه
Targeted disruption of FSCN2 gene induces retinopathy in mice.
PURPOSE To investigate the morphology and function of photoreceptors in mice with mutation of the FSCN2 gene. METHODS A mouse line was generated carrying the 208delG mutation (point mutation, or p-type) and another with replacement of exon 1 by the cDNA of a green fluorescent protein (GFP knock-in, or g-type). The expression of retinal mRNA was determined by reverse transcription (RT)-polymer...
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15 صفحه اولTargeted disruption of the murine zyxin gene.
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Activating transcription factor (ATF) 4 is a ubiquitous basic leucine-zipper transcription factor that is a member of the ATF/cyclic adenosine monophosphate responsive element-binding (CREB) protein family. To determine the in vivo function of ATF4, the ATF4 gene in murine embryonic stem cells was deleted and homozygous mutant mice were generated. ATF4 null fetuses were severely anemic because ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2001
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.21.4.1058-1065.2001